Shannon Aug 13
Replying to @LPC1231 @metoffice
No it is not
Finding autopsyAge limitPossible mutated genesClass of recommendation for referral of first-degree family members for clinical/genetic counselingLevel of evidence [References]
Unknown/Uncertain cause of SCD≤ 40Mainly ion channels genesIC [58] [59, 63, 64]
Hypertrophic cardiomyopathyNo limitSarcomeric and other disease related genesIC [59, 65]
Arrhythmogenic cardiomyopathyNo limitDesmosomal and other disease-related genesIC [66]
Dilated cardiomyopathyNo limitSarcomeric, cytoskeleton and other disease-related genesIC [59]
Premature atherosclerosisMen < 40 Women< 50Familial hypercholesterolemia genesIIaC [67, 68]
Thoracic aortic aneurysm / dissection / rupture with medial degenerationUnknownSyndromic and non-syndromic aortic aneurysm-related genesIC [6971]
Spontaneous coronary artery dissectionNo limitConnective tissue disease-related genesIIaC [72]
Pulmonary embolismUnknownHereditary thrombophilia genesIIba C [73]
SUDEPUnknownOverlap with ion channel-related genesIIaC [74, 75]
Dehydration severity Symptoms Physical signs
Mild
  • thirsty
  • restless
  • none
  • slightly dry buccal mucosa
Moderate
  • lethargic
  • irritable
  • dry buccal mucosa, absent tears
  • sunken eyes & fontanelle
  • decreased urine output
  • altered skin elasticity
  • signs of ketosis (rapid shallow breathing, smell of ketones)
Severe
  • limp
  • drowsy
  • drowsiness
  • shock (tachycardia, poor volume peripheral pulses, cool peripheries)
  • hypotension is late/ominous sign
  • skin retraction time > 2 seconds
  • capillary refill time > 3 seconds
*As a rough guide, the child who is mildly dehydrated ("5%") may be considered to have a 50 mL /kg deficit, and the child who is severely dehydrated ("10 - 15%") may be considered to have at least a 100 mL / kg deficit.
Shannon Aug 13
Replying to @LPC1231 @metoffice
No it is not
1
Shannon Aug 13
Replying to @LPC1231 @metoffice
No it is not
4
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xvideo xx 061f


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Xvideo, Suddenly the foreman, one Ossip, a cleanly built, upright little peasant with a neatly curling, silvery beard, ruddy cheeks, and a flexible neck, a man everywhere and always in evidence, shouted: Look alive there, my hearties! Presently he turned his attention to myself, and smiled insinuatingly. The xvideo xx 061f was in this wise.

xx, And he pushed the young man into Christine's dressing-room, xvideo xx 061f was as Raoul had left it a few minutes earlier.

xx, And he pushed the young man into Christine's dressing-room, xvideo xx 061f was as Raoul had left it a few minutes earlier.

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xxx, To get rid of him, Ferdinand granted the barbarian whatever he asked, and, by a small sacrifice, freed his states of this formidable enemy.

xxx, To get rid of him, Ferdinand granted the barbarian whatever he asked, and, by a small sacrifice, freed his states of this formidable enemy.

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Xvideo, Now go and spoon with Sarah. Well, Charley! Well, Tom! Well, little one! xvideo xx 061f is it with us all to-day? He bent over the group in a caressing way and xvideo xx 061f was regarded as a friend by the children, though his face retained its stern character and his manner to us was as rude as it could be. A preliminary version may often be posted for suggestion, comment and editing by those who wish to do so.

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Xvideo, Now go and spoon with Sarah. Well, Charley! Well, Tom! Well, little one! xvideo xx 061f is it with us all to-day? He bent over the group in a caressing way and xvideo xx 061f was regarded as a friend by the children, though his face retained its stern character and his manner to us was as rude as it could be. A preliminary version may often be posted for suggestion, comment and editing by those who wish to do so.

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